Stem cell-assisted wound healing is potentially a therapeutic approach for the treatment of healing-impaired wounds, in which natural wound-healing processes are not enough to prevent tissue necrosis and ischemia, partially because of an inadequate supply of growth factors and insufficient blood circulation. Although many efforts have been made to enhance chronic wounds by provding wound healing-related growth factors, clinical results have been discouraging, with only modest improvements in the length of time to closure, in breaking strength, and in neuropathy. However, stem cell therapy has several theoretical advantages over growth-factor-mediated approaches, in that transplanted stem cells not only differentiate into multiple cell types composing the skin, but also provide cytokines and growth factors required for wound healing.
Wound Management
